Autism spectrum disorder: An omics perspective

作者：Woods Alisa G; Wormwood Kelly L; Wetie Armand G Ngounou; Aslebagh Roshanak; Crimmins Bernard S; Holsen Thomas M; Darie Costel C^*

来源：Proteomics - Clinical Applications, 2015, 9(1-2): 159-168.

DOI：10.1002/prca.201400116

• Autism spectrum disorder
• Neurodevlopmental disorders

Current directions in autism spectrum disorder (ASD) research may require moving beyond genetic analysis alone, based on the complexity of the disorder, heterogeneity and convergence of genetic alterations at the cellular/functional level. Mass spectrometry (MS) has been increasingly used to study CNS disorders, including ASDs. Proteomic research using MS is directed at understanding endogenous protein changes that occur in ASD. This review focuses on how MS has been used to study ASDs, with particular focus on proteomic analysis. Other neurodevelopmental disorders have been investigated using MS, including fragile X syndrome (FXS) and Smith-Lemli-Opitz Syndrome (SLOS), genetic syndromes highly associated with ASD comorbidity.

• 出版日期2015-2