Advances in Acylation Methodologies Enabled by Oxyma-Based Reagents

作者：Subiros Funosas Ramon^*; Khattab Sherine N; Nieto Rodriguez Lidia; El Faham Ayman; Albericio Fernando

来源：Aldrichimica Acta, 2013, 46(1): 21-40.

• oximes
• Oxyma
• COMU (R)
• acylation
• coupling reagents
• additives
• peptide synthesis
• amide
• ester

The aim of this review is to cover recent advances in acylation chemistry (peptide, amide, and ester bond formation) in which ethyl 2-cyano-2-(hydroxyimino)acetate (Oxyma)-derived reagents are involved. The distinct applications of each class of Oxyma derivatives will be discussed and compared to the behavior of reputed standards in the field.

• 出版日期2013