Novel functions of B cells in transplantation

作者：Platt Jeffrey L; Tsuji Shoichiro; Cascalho Marilia^*

来源：Current Opinion in Organ Transplantation, 2011, 16(1): 61-68.

DOI：10.1097/MOT.0b013e328342551c

• B cell depletion therapy
• B cells
• regulatory B cells
• T cells
• transplantation

Purpose of review
This manuscript reviews current knowledge and recent findings regarding antibody-independent functions of B cells in transplantation.
Recent findings
Until recently the functions of B cells in transplantation have been attributed almost entirely to the antibodies they produce. However, the results of recent trials of B-cell-depleting agents for treatment of antibody-mediated rejection as well as auto-immune disease raised awareness that B cells mediate functions independent of antibody synthesis.
Summary
These 'nonclassical' functions place B cells at the center of immune regulation with the power to enhance or inhibit immunity.

• 出版日期2011-2