Alfaxalone versus propofol in dogs: a randomised trial to assess effects on peri-induction tear production, intraocular pressure and globe position

作者：Costa Daniel; Leiva Marta^*; Moll Xavier; Aguilar Adria; Pena Teresa; Andaluz Anna

来源：The Veterinary Record, 2015, 176(3): 73-73.

DOI：10.1136/vr.102621

The purpose of this randomised trial was to compare the effects of alfaxalone and propofol on tear production (STT-1), intraocular pressure (IOP) and globe position (GP) in healthy dogs. Fourteen Beagles were randomly divided into two groups; dogs in one group received alfaxalone (3 mg/kg) (n = 7) and dogs in the other group received propofol (6 mg/kg) (n = 7), both administered intravenously. IOP and GP were evaluated at basal time (T-b) and T-2,T-5,T-10,T-15,T-20,T-25&30 (minutes after complete drug administration). STT-1 was evaluated at T-b and T-10,T-20&30. STT-1 and IOP results were analysed using analysis of variance and GP was analysed using the likelihood ratio chi(2) test. Dogs in the alfaxalone group showed a significant reduction in STT-1 at T-10&20 (P < 0.05), while the propofol group did not show statistically significant differences in this parameter over time. Both anaesthetic drugs produced a transient elevation of IOP at T-2 (P > 0.05), which then decreased (P < 0.01). While alfaxalone caused a ventral globe deviation that lasted from T-2 to T-10 (P < 0.05) and was fully recovered at T-30, propofol induced a ventral globe deviation from T-2 to T-5 (P < 0.05), being restored at T-20. These results suggest that both alfaxalone and propofol can be safely used for intraocular surgery, as they significantly reduce IOP. Furthermore, anaesthetic induction with propofol would be especially recommended for dogs with tear deficiencies.

• 出版日期2015-1-17