Altered Effector CD4(+) T Cell Function in IL-21R(-/-) CD4(+) T Cell-Mediated Graft-Versus-Host Disease

作者：Oh Iekuni; Ozaki Katsutoshi^*; Meguro Akiko; Hatanaka Keiko; Kadowaki Masanori; Matsu Haruko; Tatara Raine; Sato Kazuya; Iwakura Yoichiro; Nakae Susumu; Sudo Katsuko; Teshima Takanori; Leonard Warren J; Ozawa Keiya

来源：The Journal of Immunology, 2010, 185(3): 1920-1926.

DOI：10.4049/jimmunol.0902217

We previously showed that transplantation with IL-21R gene-deficient splenocytes resulted in less severe graft-versus-host disease (GVHD) than was observed with wild type splenocytes. In this study, we sought to find mechanism(s) explaining this observation. Recipients of donor CD4(+) T cells lacking IL-21R exhibited diminished GVHD symptoms, with reduced inflammatory cell infiltration into the liver and intestine, leading to prolonged survival. After transplantation, CD4(+) T cell numbers in the spleen were reduced, and MLR and cytokine production by CD4(+) T cells were impaired. These results suggest that IL-21 might promote GVHD through enhanced production of effector CD4(+) T cells. Moreover, we found that CD25 depletion altered neither the impaired MLR in vitro nor the ameliorated GVHD symptoms in vivo. Thus, the attenuated GVHD might be caused by an impairment of effector T cell differentiation itself, rather than by an increase in regulatory T cells and suppression of effector T cells. The Journal of Immunology, 2010, 185: 1920-1926.

• 出版日期2010-8-1
• 单位河北医科大学