Aortic stiffness is associated with the central retinal arteriolar equivalent and retinal vascular fractal dimension in a population along the southeastern coast of China

作者：Lin, Fan; Zhu, Pengli^*; Huang, Feng; Li, Qiaowei; Yuan, Yin; Gao, Zhonghai; Yu, Peng; Lin, Jing; Chen, Falin

来源：Hypertension Research, 2015, 38(5): 342-348.

DOI：10.1038/hr.2015.11

• aortic stiffness
• central retinal arteriolar
• fractal dimension

The objective of this study was to evaluate the association of the central retinal arteriolar equivalent (CRAE) and the retinal vascular fractal dimension, two quantitative parameters that reflect microcirculation, with aortic stiffness. In this cross-sectional study, we identified the cardiovascular risk factors in 2169 subjects using a health questionnaire, physical examinations and laboratory examinations. We evaluated the aortic stiffness using noninvasive brachial-ankle pulse wave velocity (baPWV) and assessed the microcirculatory alterations with CRAE and retinal vascular fractal dimension, which were measured using fundus photography and semiautomatic quantitative software, respectively. The increase in baPWV (Q1-Q4) correlated with an increased likelihood of the central retinal artery narrowing and a reduction in the retinal vascular fractal dimension. Further adjustment of the cardiovascular risk factors diminished the association between baPWV and CRAE, but increased the association between baPWV and retinal vascular fractal dimension. Elevated baPWV correlates with reduced CRAE and retinal vascular fractal dimension. Such a finding supports macrocirculation-and microcirculation-associated hypotheses.

• 出版日期2015-5
• 单位福建医科大学; 福建省立医院