科研之友
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摘要
Aims To investigate associations between changes in retinal vessels and alterations detected by spectral domain optical coherence tomography (SD-OCT) scans in intermediate stage age-related macular degeneration (AMD). Methods Thirty eyes of 30 patients with intermediate dry AMD were enrolled in the study. Of the cohort study, 15 eyes (changes-AMD group) showed OCT changes preceding the development of drusen-associated atrophy. A control group of healthy subjects was selected for statistical comparisons. All patients underwent an ophthalmologic evaluation, including OCT angiography (OCTA) and SD-OCT scans. Main outcome measures were superficial vessel density, deep vessel density, macular thickness. Results Foveal macular thickness was 215.2 +/- 32.9 mu m in changes-AMD patients and was significantly thinner than no changes-AMD patients (248.3 +/- 23.3 mu m, p=0.002) and healthy subjects (268.1 +/- 19.2 mu m, p<0.0001). Furthermore, in the parafoveal area, the thicknesses of both the inner retina and the outer retina were reduced in the changes-AMD group, after comparison with the two other groups. Parafoveal superficial vascular plexus flow density was 43.3 +/- 2.7% in changes-AMD patients and was decreased compared with the no changes-AMD group (48.7 +/- 3.3%, p=0.003) and healthy controls (50.4 +/- 6.1%, p=0.001). A direct correlation of the superficial plexus flow density with the inner retina parafoveal macular thickness (R-2=0.761, p=0.028) was found. Conclusions We demonstrated an association between SD-OCT signs and retinal blood supply in patients with intermediate AMD and we showed that patients with signs predicting development of geographic atrophy have a reduced flow in superficial vascular plexus and damage of the inner and the outer retina.
- 出版日期2017-6
