ANXA9 gene expression in colorectal cancer: A novel marker for prognosis

作者：Miyoshi Norikatsu^*; Yamamoto Hirofumi; Mimori Koshi; Yamashita Shinya; Miyazaki Susumu; Nakagawa Sumiko; Ishii Hideshi; Noura Shingo; Ohue Masayuki; Yano Masahiko; Doki Yuichiro; Mori Masaki

来源：Oncology Letters, 2014, 8(5): 2313-2317.

DOI：10.3892/ol.2014.2477

• ANXA9
• prognosis
• colorectal cancer

Annexin A9 (ANXA9) is involved with the interaction with membrane phospholipids in a Ca2+-dependent manner. A previous study has shown that ANXA9 expression is associated with bone metastasis in breast cancer, whereas its significance in colorectal cancer (CRC) is unknown. The present study was comprised of 100 patients who underwent surgery for CRC. The correlation between gene expression and the clinical parameters of the patients was assessed. Patients with high ANXA9 expression were statistically susceptible to a relatively worse prognosis, and those with low ANXA9 expression showed improved overall survival compared with those with high expression. In conclusion, the present data suggests that ANXA9 expression is a prognostic factor in CRC patients.

• 出版日期2014-11