A New DNA-Intercalative Cytotoxic Allylic Xanthone from Swertia corymbosa

作者：Uvarani Chokkalingam; Arumugasamy Karuppannan; Chandraprakash Kumarasamy; Sankaran Mathan; Ata Athar^*; Mohan Palathurai Subramaniam

来源：Chemistry and Biodiversity, 2015, 12(3): 358-370.

DOI：10.1002/cbdv.201400055

• Swertia corymbosa
• Xanthones
• Antioxidant activity
• Anti--glucosidase activity
• Cytotoxic activity
• Protein binding
• DNA

Phytochemical investigation of the CHCl3 fraction of Swertia corymbosa resulted in the isolation of a new 3-allyl-2,8-dihydroxy-1,6-dimethoxy-9H-xanthen-9-one (1), along with four known xanthones, gentiacaulein (3), norswertianin (4), 1,3,6,8-tetrahydroxyxanthone (5), and 1,3-dihydroxyxanthone (6). Structure of compound 1 was elucidated with the aid of IR, UV, NMR, and MS data, and chemical transformation via new allyloxy xanthone derivative (2). Compounds 1-6 exhibited various levels of antioxidant and anti--glucosidase activities. Absorption and fluorescence spectroscopic studies on 1-6 indicated that these compounds could interact with calf thymus DNA (CT-DNA) through intercalation and with bovine serum albumin (BSA) in a static quenching process. Compound 1 was found to be significantly cytotoxic against human cancer cell lines HeLa, HCT116, and AGS, and weakly active against normal NIH 3T3 cell line.

• 出版日期2015-3