ATGs help MHC class II, but inhibit MHC class I antigen presentation

作者：Loi Monica; Gannage Monique; Munz Christian^*

来源：Autophagy, 2016, 12(9): 1681-1682.

DOI：10.1080/15548627.2016.1203488

• AAK1
• Atg8
• LC3
• influenza virus
• intracellular antigen processing
• LC3-associated phagocytosis

We have recently shown that the LC3/Atg8 lipidation machinery of macroautophagy is involved in the internalization of MHC class I molecules. Decreased internalization in the absence of ATG5 or ATG7 leads to MHC class I surface stabilization on dendritic cells and macrophages, resulting in elevated CD8(+) T cell responses during viral infections and improved immune control. Here, we discuss how the autophagic machinery supports MHC class II restricted antigen presentation, while compromising MHC class I presentation via internalization and degradation.

• 出版日期2016