A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa

作者：Li, Meng; Wang, Xiaolan; Zheng, Xiaoke; Wang, Jianchao; Zhao, Wei; Song, Kai; Zhao, Xuan; Zhang, Yanli; Kuang, Haixue; Feng, Weisheng^*

来源：Molecules, 2015, 20(8): 15192-15201.

DOI：10.3390/molecules200815192

• Rehmannia glutinosa
• ionone glycoside
• rhemaneolignans
• the protective effects of cardiomyocytes

A new ionone glycoside, frehmaglutoside I (1), and three new rhemaneolignans A-C (2-4) were isolated from the 95% EtOH extract of the roots of Rehmannia glutinosa. Their structures were determined by extensive spectroscopic (UV, IR, HR-ESI-MS, 1D and 2D NMR) analyses. In addition, these compounds were evaluated for their protective effects on cardiocytes impaired by doxorubicin in H9c2 cells. Among them, compounds 1-3 exhibited protective effects against DOX-induced cardiotoxicity.

• 出版日期2015-8
• 单位河南中医药大学; 黑龙江中医药大学