Augmentation of Clozapine with Pimozide: A Case of a Treatment-Resistant Schizophrenic Patient

作者：Akdag Hatice Alkan^*; Kisa Cebrail; Bekki Guelcan; Goka Erol

来源：Noropsikiyatri Arsivi, 2010, 47(1): 74-77.

• Clozapine
• treatment resistant schizophrenia
• augmentation
• pimozide

In the treatment of resistant schizophrenic patients, the preferred monotherapy of clozapine, does not result in sufficient treatment response in 40-70% of the cases. The high rate of treatment unresponsiveness has led clinicians to augment clozapine with other pharmacological agents. To date, many clinical and case studies have been conducted. In related studies, clozapine has been combined with various drugs, such as typical and atypical antipsychotics, several antidepressants, mood stabilizers, bromocriptine and glycine. However, up-to-date research study results are not sufficient to support the augmentation of clozapine therapy approaches. The augmentation of clozapine with pimozide has been a rarely preferred approach. In this paper, a case of a patient is presented, who was followed with the diagnosis of treatment-resistant disorganized schizophrenia and whose clozapine treatment was augmented with pimozide. The presented history reveals that only the combination of clozapine with pimozide was beneficial for this particular patient, whose symptoms relapsed after the cessation of the drugs, and who apparently benefited from treatment when this combination was initiated again. (Archives of Neuropsychiatry 2010; 47: 74-7)

• 出版日期2010