A novel caryophyllene type sesquiterpene lactone from Asparagus falcatus (Linn.); Structure elucidation and anti-angiogenic activity on HUVECs

作者：Ghalib Raza Murad^*; Hashim Rokiah; Sulaiman Othman; Mehdi Sayed Hasan; Valkonen Arto; Rissanen Kari; Trifunovic Srecko R; Ahamed Mohamed B Khadeer; Majid Amin Malik Shah Abdul; Kawamura Fumio

来源：European Journal of Medicinal Chemistry, 2012, 47: 601-607.

DOI：10.1016/j.ejmech.2011.10.037

• Asparagus falcatus (Linn.)
• Aspfalcolide
• Crystal structure
• Anti-angiogenic activity
• HUVECs

In this study the novel caryophyllene type sesquiterpene lactone (aspfalcolide) has been isolated from the leaves of Asparagus falcatus (Linn.) and characterized by IR, 1D NMR, 2D NMR, El-MS, HR-ESI-MS and X-ray single crystal diffraction analysis. The aspfalcolide crystallizes in the orthorhombic space group P2(1)2(1)2(1) with a = 6.37360(10), b = 7.6890(2), c = 27.3281(6) angstrom, alpha = beta = gamma = 90 degrees and Z = 4. One inter-molecular O-H center dot center dot center dot O hydrogen bond enforces these natural molecules to form infinite chains through the crystal. Aspfalcolide was screened for its anti-angiogenic activity in human umbilical vein endothelial cells (HUVECs) and the result showed the remarkable inhibitory effect of aspfalcolide on the proliferation (IC50 1.82 mu M), migration and tube formation of HUVECs.

• 出版日期2012-1