Modulation of dendritic cell innate and adaptive immune functions by oral and sublingual immunotherapy

作者：Frischmeyer Guerrerio Pamela A^*; Keet Corinne A; Guerrerio Anthony L; Chichester Kristin L; Bieneman Anja P; Hamilton Robert G; Wood Robert A; Schroeder John T

来源：Clinical Immunology, 2014, 155(1): 47-59.

DOI：10.1016/j.clim.2014.08.006

• Dendritic cell
• Food allergy
• Immunotherapy
• Innate immunity
• Adaptive immunity
• Tolerance

Sublingual (SLIT) and oral immunotherapy (OIT) are promising treatments for food allergy, but underlying mechanisms are poorly understood. Dendritic cells (DCs) induce and maintain Th2-type allergen-specific T cells, and also regulate innate immunity through their expression of Toll-like receptors (TLRs). We examined how SLIT and OIT influenced DC innate and adaptive immune responses in children with IgE-mediated cow's milk (CM) allergy. SLIT, but not OIT, decreased TLR-induced IL-6 secretion by myeloid DCs (mDCs). SLIT and OIT altered mDC IL-10 secretion, a potent inhibitor of Fc epsilon RI-dependent pro-inflammatory responses. OIT uniquely augmented IFN-alpha and decreased IL-6 secretion by plasmacytoid DCs (pDCs), which was associated with reduced TLR-induced IL-13 release in pDC-T cell co-cultures. Both SLIT and OIT decreased Th2 cytokine secretion to CM in pDC-T, but not mDC-T, co-cultures. Therefore, SLIT and OIT exert unique effects on DC-driven innate and adaptive immune responses, which may inhibit allergic inflammation and promote tolerance.

• 出版日期2014-11