Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI)

作者：Nathan Pradeep J^*; Lim Yen Ying^*; Abbott Rosemary; Galluzzi Samantha; Marizzoni Moira; Babiloni Claudio; Albani Diego; Bartres Faz David; Didic Mira; Farotti Lucia; Parnetti Lucilla; Salvadori Nicola; Mueller Bernhard W; Forloni Gianluigi; Girtler Nicola; Hensch Tilman; Jovicich Jorge; Leeuwis Annebet; Marra Camillo; Luis Molinuevo Jose; Nobili Flavio; Pariente Jeremie; Payoux Pierre; Ranjeva Jean Philippe; Rolandi Elena; Rossini Paolo Maria; Schoenknecht Peter

来源：Neurobiology of Aging, 2017, 53: 1-10.

DOI：10.1016/j.neurobiolaging.2017.01.013

• Mild cognitive impairment
• Prodromal
• Alzheimer's disease
• Cognitive assessment
• CANTAB
• CSF
• Amyloid
• Tau
• Hippocampal volume

Few studies have examined the relationship between CSF and structural biomarkers, and cognitive function in MCI. We examined the relationship between cognitive function, hippocampal volume and cerebrospinal fluid (CSF) A beta 42 and tau in 145 patients with MCI. Patients were assessed on cognitive tasks from the Cambridge Neuropsychological Test Automated Battery (CANTAB), the Geriatric Depression Scale and the Functional Activities Questionnaire. Hippocampal volume was measured using magnetic resonance imaging (MRI), and CSF markers of A beta 42, tau and p-tau181 were also measured. Worse performance on a wide range of memory and sustained attention tasks were associated with reduced hippocampal volume, higher CSF tau and p-tau181 and increased tau/A beta 42 ratio. Memory tasks were also associated with lower ability to conduct functional activities of daily living, providing a link between AD biomarkers, memory performance and functional outcome. These results suggest that biomarkers of Ab and tau are strongly related to cognitive performance as assessed by the CANTAB, and have implications for the early detection and characterization of incipient AD.

• 出版日期2017-5