A case report of differentiating staphylococcal scalded skin syndrome and toxic epidermal necrolysis by optical coherence tomography

作者：Hussain A A^*; Banzhaf C A; Themstrup L; Nielsen P L; Jemec G B E

来源：Skin Research and Technology, 2015, 21(3): 363-365.

DOI：10.1111/srt.12200

• Staphylococcal scalded skin syndrome
• toxic epidermal necrolysis
• optical coherence tomography
• skin imaging
• diagnostic imaging

BackgroundStaphylococcal scalded skin syndrome (SSSS) and toxic epidermal necrolysis (TEN) both present with acute onset, high morbidity and significant mortality. Rapid diagnosis is therefore of importance. The aim of this study was to investigate and compare the presentation of these diseases using optical coherence tomography (OCT).
MethodsTwo male patients with bullous diseases, SSSS and TEN, respectively, were photographed digitally, examined using dermoscopy, OCT scanned and subsequently biopsied in the said order.
ResultsThe bullous skin was visualized by OCT showing two distinct images: the SSSS-patient displayed superficial hyporefletive flaccid structures with a split high in the thickened (0.51mm vs. 0.12mm) epidermis while the TEN-patient demonstrated a larger hyporeflective ovoid structure with a split right below the thickened epidermis (0.18mm vs. 0.06mm).
ConclusionThese findings suggest that there is a potential for the application of OCT scanning in the acute phase of SSSS and TEN in order to distinguish them for a faster diagnosis and better management and treatment.

• 出版日期2015-8