MicroRNA-124 mediates the cholinergic anti-inflammatory action through inhibiting the production of pro-inflammatory cytokines

作者：Sun Yang; Li Qi; Gui Huan; Xu Dong Ping; Yang Yi Li; Su Ding Feng; Liu Xia^*

来源：Cell Research, 2013, 23(11): 1270-1283.

DOI：10.1038/cr.2013.116

• microRNA-124
• cholinergic anti-inflammatory action
• alpha 7nAChR
• macrophages
• septic shock
• STAT3
• TACE

The vagus nerve can control inflammatory response through a %26apos;cholinergic anti-inflammatory pathway%26apos;, which is mediated by the alpha 7-nicotinic acetylcholine receptor (alpha 7nAChR) on macrophages. However, the intracellular mechanisms that link alpha 7nAChR activation and pro-inflammatory cytokine production remain not well understood. In this study, we found that miR-124 is upregulated by cholinergic agonists in LPS-exposed cells and mice. Utilizing miR-124 mimic and siRNA knockdown, we demonstrated that miR-124 is a critical mediator for the cholinergic anti-inflammatory action. Furthermore, our data indicated that miR-124 modulates LPS-induced cytokine production by targeting signal transducer and activator of transcription 3 (STAT3) to decrease IL-6 production and TNF-alpha converting enzyme (TACE) to reduce TNF-alpha release. These results also indicate that miR-124 is a potential therapeutic target for the treatment of inflammatory diseases.

• 出版日期2013-11
• 单位中国人民解放军第二军医大学