Multipotent adult progenitor cells sustain function of ischemic limbs in mice

作者：Aranguren Xabier L; McCue Jonathan D; Hendrickx Benoit; Zhu Xiao Hong; Du Fei; Chen Eleanor; Pelacho Beatriz; Penuelas Ivan; Abizanda Gloria; Uriz Maialen; Frommer Sarah A; Ross Jeffrey J; Schroeder Betsy A; Seaborn Meredith S; Adney Joshua R; Hagenbrock Julianna; Harris Nathan H; Zhang Yi; Zhang Xiaoliang; Nelson Holte Molly H; Jiang Yuehua; Billiau An D; Chen Wei; Prosper Felipe; Verfaillie Catherine M; Luttun Aernout^*

来源：Journal of Clinical Investigation, 2008, 118(2): 505-514.

DOI：10.1172/JC131153

Despite progress in cardiovascular research, a cure for peripheral vascular disease has not been found. We compared the vascularization and tissue regeneration potential of murine and human undifferentiated multipotent adult progenitor cells (mMAPC-U and hMAPC-U), murine MAPC-derived vascular progenitors (mMAPC-VP), and unselected murine BM cells (mBMCs) in mice with moderate limb ischemia, reminiscent of intermittent claudication in human patients. mMAPC-U durably restored blood flow and muscle function and stimulated muscle regeneration, by direct and trophic contribution to vascular and skeletal muscle growth. This was in contrast to mBMCs and mMAPC-VP, which did not affect muscle regeneration and provided only limited and transient improvement. Moreover, mBMCs participated in a sustained inflammatory response in the lower limb, associated with progressive deterioration in muscle function. Importantly, mMAPC-U and hMAPC-U also remedied vascular and muscular deficiency in severe limb ischemia, representative of critical limb ischemia in humans. Thus, unlike BMCs or vascular-committed progenitors, undifferentiated multipotent adult progenitor cells offer the potential to durably repair ischemic damage in peripheral vascular disease patients.

• 出版日期2008-2