Ayurvedic formulations as therapeutic radioprotectors: preclinial studies on Brahma Rasayana and Chyavanaprash

作者：Aditya Menon; Nair C K K^*

来源：Current Science, 2013, 104(7): 959-966.

• Antioxidant
• Brahma Rasayana
• cellular repair index
• Chyavanaprash
• DNA damage

Exposure to ionizing radiation reduces the cellular antioxidants and causes damage to genomic DNA. In the mammalian system, this results in various radiation syndromes depending on the radiation dose. Commercially available ayurvedic formulations, Brahma Rasayana (BRM) and Chyavanaprash (CHM) were analysed for their ability to restore the cellular antioxidant status and enhance the repair of radiation-induced DNA damages. The antioxidant status in various tissues of mice was restored when these formulations were orally administered, following whole-body exposure to gamma radiation. Administration of these formulations to 4 Gy whole-body gamma-irradiated mice resulted in faster cellular DNA repair, as revealed from the increased cellular repair index and decrease in the formation of micronucleus. This work suggests the possibility of using BRM or CHM as a therapeutic radioprotector during unplanned, accidental ionizing radiation exposure scenario.

• 出版日期2013-4-10
• 单位河北医科大学