Differential Diagnosis of Degenerative Dementias Using Basic Neuropsychological Tests: Multivariable Logistic Regression Analysis of 301 Patients

作者：Jimenez Huete Adolfo^*; Riva Elena; Toledano Rafael; Campo Pablo; Esteban Jesus; Del Barrio Antonio; Franch Oriol

来源：American Journal of Alzheimer's Disease and Other Dementias, 2014, 29(8): 723-731.

DOI：10.1177/1533317514534954

• dementia
• Alzheimer disease
• Lewy body disease
• frontotemporal lobar degeneration
• diagnosis
• differential
• demography
• neuropsychological tests
• and logistic models

Background: The validity of neuropsychological tests for the differential diagnosis of degenerative dementias may depend on the clinical context. We constructed a series of logistic models taking into account this factor. %26lt;br%26gt;Methods: We retrospectively analyzed the demographic and neuropsychological data of 301 patients with probable Alzheimer%26apos;s disease (AD), frontotemporal degeneration (FTLD), or dementia with Lewy bodies (DLB). Nine models were constructed taking into account the diagnostic question (eg, AD vs DLB) and subpopulation (incident vs prevalent). %26lt;br%26gt;Results: The AD versus DLB model for all patients, including memory recovery and phonological fluency, was highly accurate (area under the curve = 0.919, sensitivity = 90%, and specificity = 80%). The results were comparable in incident and prevalent cases. The FTLD versus AD and DLB versus FTLD models were both inaccurate. %26lt;br%26gt;Conclusion: The models constructed from basic neuropsychological variables allowed an accurate differential diagnosis of AD versus DLB but not of FTLD versus AD or DLB.

• 出版日期2014-12