MTHFR functional genetic variation and methotrexate treatment response in rheumatoid arthritis: a meta-analysis

作者：Morgan Michael D; Al Shaarawy Nashwa; Martin Steve; Robinson James I; Twigg Sarah; Magdy Awadalla A; Omar Aziza Sayed; Ghattas Maivel H; Emery Paul; Barrett Jennifer H; Morgan Ann W^*

来源：Pharmacogenomics, 2014, 15(4): 467-475.

DOI：10.2217/pgs.13.235

• Type 2 diabetes mellitus
• pharmacogenetics
• biguanide
• metformin
• antidiabetic

Aim: To date, functional MTHFR SNPs have been tested for their impact on low-dose methotrexate (MTX) response in small rheumatoid arthritis (RA) cohorts. We sought to test their effect in the single largest cohort studied to date, and undertook a meta-analysis utilizing stringent study inclusion criteria. Materials & methods: RA patients treated with MTX monotherapy from the Yorkshire Early Arthritis Register (YEAR) were genotyped using RFLP assays, and tested for association with treatment efficacy. Studies for meta-analysis were screened by a set of stringent inclusion criteria. Results & conclusion: rs1801131 and rs1801133 were not associated with response to MTX in the YEAR cohort, nor did they affect the probability of achieving a low disease activity state. A meta-analysis of comparable studies found no association with these SNPs. MTHFR SNPs rs1801131 and rs1801133 are unlikely to have a clinically meaningful effect on the first 6 months of MTX treatment in early RA.

• 出版日期2014-3