A Facile and Efficient Synthesis of Novel Pyrimido[5,4-b][4,7]phenanthroline-9,11(7H,8H,10H,12H)-dione derivatives via Microwave-assisted Multicomponent Reactions

作者：Shi Feng; Yan Shu; Zhou Dianxiang; Tu Shujiang^*; Zou Xiang; Hao Wenjuan; Zhang Xiaohong; Han Zhengguo; Wu Shanshan; Cao Xudong

来源：Journal of Heterocyclic Chemistry, 2009, 46(3): 563-566.

DOI：10.1002/jhet.116

A series of novel pyrimido[5,4-b][4,7]phenanthroline-9,11(7H,8H,10H,12H)-dione derivatives were synthesized via microwave-assisted three-component reactions of barbituric acid, aldehyde, and quinolin-6-amine in DMF without catalyst. This facile synthesis not only offers an economical and efficient synthetic strategy to this class of significant compounds but also enriches the investigations on microwave-assisted multicomponent reactions. Moreover, this protocol has the prominent advantages of short reaction time, good yields, low cost, easy operation, as well as environmental-friendliness.

• 出版日期2009-5
• 单位江苏师范大学