Acute Atrial Dilatation Slows Conduction and Increases AF Vulnerability in the Human Atrium

作者:Ravelli Flavia*; Mase Michela; Del Greco Maurizio; Marini Massimiliano; Disertori Marcello
来源:Journal of Cardiovascular Electrophysiology, 2011, 22(4): 394-401.
DOI:10.1111/j.1540-8167.2010.01939.x

摘要

Methods and Results: Electroanatomic mapping of right atrial activation was performed in 10 patients during coronary sinus pacing under control condition and during acute atrial dilatation. Atrial stretch was obtained by simultaneous atrioventricular (AV) pacing at a cycle length of 450-500 ms. Local CVs were accurately estimated by applying the principle of triangulation and spatially mapped over the whole right atrial endocardial surface. Simultaneous AV pacing significantly increased right atrial volume from 72.0 +/- 29.0 to 86.3 +/- 31.3 mL (P < 0.001). The 23% increase in atrial volume resulted in an overall decrease in atrial CV from 65.8 +/- 5.9 to 55.2 +/- 7.2 cm/s (P < 0.001) and an increased incidence of slow conduction sites or local conduction blocks from 10.3 +/- 4.2% to 15.9 +/- 7.7% (P < 0.01). Acute atrial dilatation concurrently increased AF vulnerability, with 6 of 10 patients developing AF episodes under stretch condition.
Conclusion: Quantification of stretch-induced conduction changes in the human atrium is feasible by combining simultaneous AV pacing and CV map construction. Acute atrial dilatation results in conduction slowing and significant increase in AF vulnerability, suggesting the role of stretch-induced conduction disturbances in the creation of a substrate for AF. (J Cardiovasc Electrophysiol, Vol. 22, pp. 394-401).

  • 出版日期2011-4