Prolonged Sinus Tachycardia Caused by Human Herpesvirus 6 (HHV6) Encephalomyelitis after Allogeneic Bone Marrow Transplantation

作者：Nishimoto Mitsutaka; Nakamae Hirohisa^*; Hayashi Yoshiki; Koh Hideo; Nakane Takahiko; Yoshida Masahiro; Bingo Masato; Okamura Hiroshi; Aimoto Mizuki; Nanno Satoru; Yoshimura Takuro; Inaba Akiko; Hagihara Kiyoyuki; Nakamae Mika; Hirose Asao; Nakao Yoshitaka; Terada Yoshiki; Hino Masayuki

来源：Internal Medicine, 2012, 51(10): 1265-1267.

DOI：10.2169/internalmedicine.51.6640

• human herpesvirus 6 (HHV6)
• encephalomyelitis
• dysautonomia
• sinus tachycardia

A 19-year-old man with Philadelphia chromosome-positive acute lymphoblastic leukemia received an allogeneic hematopoietic cell transplant with unrelated bone marrow. On day 20, the patient developed impaired consciousness and disorientation. Examination of the cerebrospinal fluid showed 2x10(4) copies/mL of HHV6B. HHV6 encephalitis was diagnosed, as had HHV6 myelitis based on symptoms that included lancinating pain/pruritus in the lower limbs and dysuria/dyschezia. Concurrently, he showed sinus tachycardia. Even after clearance of the HHV6 genome from the plasma and CSF was achieved by treatment with foscarnet, sinus tachycardia persisted for another 100 days. We suspected prolonged sinus tachycardia due to dysautonomia caused by HHV6 encephalomyelitis.

• 出版日期2012