Gold nanoparticles obtained by aqueous digestive ripening: Their application as X-ray contrast agents

作者：Silvestri Alessandro; Polito Laura^*; Bellani Giacomo; Zambelli Vanessa; Jumde Ravindra P; Psaro Rinaldo; Evangelisti Claudio

来源：Journal of Colloid and Interface Science, 2015, 439: 28-33.

DOI：10.1016/j.jcis.2014.10.025

• Au nanoparticles
• Metal vapor synthesis
• Digestive ripening
• X-ray contrast agents

A preparative protocol to synthesize large quantities of size-controlled gold nanopartides (Au NPs), stabilized by CH3O-PEG(5000)-SH (PEG-SH) in aqueous medium, is reported. The combination of metal vapor synthesis (MVS) technique with digestive ripening process allowed to obtain PEGylated Au NPs with mean core particle size of 3.8 nm and hydrodynamic diameters centered at 8.0 nm which were effectively used as computed tomography (CT) contrast agents for in vivo experiments on mice. The surface functionalization together with the small hydrodynamic diameters of the engineered Au nanoparticles permitted their efficient renal clearance, still retaining a prolonged blood circulation and a stealth capability.

• 出版日期2015-2-1