Ceftriaxone, an FDA-approved cephalosporin antibiotic, suppresses lung cancer growth by targeting Aurora B

作者：Li Xiang; Li Haitao; Li Shengqing; Zhu Feng; Kim Dong Joon; Xie Hua; Li Yan; Nadas Janos; Oi Naomi; Zykova Tatyana A; Yu Dong Hoon; Lee Mee Hyun; Kim Myoung Ok; Wang Lei; Ma Weiya; Lubet Ronald A; Bode Ann M; Dong Ziming; Dong Zigang

来源：Carcinogenesis, 2012, 33(12): 2548-2557.

DOI：10.1093/carcin/bgs283

Ceftriaxone, an FDA-approved third-generation cephalosporin antibiotic, has antimicrobial activity against both gram-positive and gram-negative organisms. Generally, ceftriaxone is used for a variety of infections such as community-acquired pneumonia, meningitis and gonorrhea. Its primary molecular targets are the penicillin-binding proteins. However, other activities of ceftriaxone remain unknown. Herein, we report for the first time that ceftriaxone has antitumor activity in vitro and in vivo. Kinase profiling results predicted that Aurora B might be a potential ooff'; target of ceftriaxone. Pull-down assay data confirmed that ceftriaxone could bind with Aurora B in vitro and in A549 cells. Furthermore, ceftriaxone (500 M) suppressed anchorage-independent cell growth by targeting Aurora B in A549, H520 and H1650 lung cancer cells. Importantly, in vivo xenograft animal model results showed that ceftriaxone effectively suppressed A549 and H520 lung tumor growth by inhibiting Aurora B. These data suggest the anticancer efficacy of ceftriaxone for the treatment of lung cancers through its inhibition of Aurora B.

• 出版日期2012-12
• 单位郑州大学