Minimally invasive versus the conventional open surgical approach of a radical cholecystectomy for gallbladder cancer: a retrospective comparative study

作者：Agarwal Anil K^*; Javed Amit; Kalayarasan Raja; Sakhuja Puja

来源：Hepato Pancreato Biliary, 2015, 17(6): 536-541.

DOI：10.1111/hpb.12406

BackgroundLaparoscopic surgery has traditionally been contraindicated for the management of gall bladder cancer (GBC). This study was undertaken to determine the safety and feasibility of a laparoscopic radical cholecystectomy (LRC) for GBC and compare it with an open radical cholecystectomy (ORC).
MethodsRetrospective analysis of primary GBC patients (with limited liver infiltration) and incidental GBC (IGBC) patients (detected after a laparoscopic cholecystectomy) who underwent LRC between June 2011 and October 2013. Patients who fulfilled the study criteria and underwent ORC during the same period formed the control group.
ResultsDuring the study period, 147 patients with GBC underwent a radical cholecystectomy. Of these, 24 patients (primary GBC- 20, IGBC - 4) who underwent a LRC formed the study group (Group A). Of the remaining 123 patients who underwent ORC, 46 matched patients formed the control group (Group B). The median operating time was higher in Group A (270 versus 240 mins, P=0.021) and the median blood loss (ml) was lower (200 versus 275 ml, P=0.034). The post-operative morbidity and mortality were similar (P=1.0). The pathological stage of the tumour in Group A was T-1b (n=1), T-2 (n=11) and T-3 (n=8), respectively. The median lymph node yield was 10 (4-31) and was comparable between the two groups (P=0.642). During a median follow-up of 18 (6-34) months, 1 patient in Group A and 3 in Group B developed recurrence. No patient developed a recurrence at a port site.
ConclusionLRC is safe and feasible in selected patients with GBC, and the results were comparable to ORC in this retrospective comparison.

• 出版日期2015-6