Phytochemicals from the aerial parts of Ligularia thomsonii and their radical scavenging activity

作者：Hussain Syed Hamid^*; Latif Abdul; Cox Russell J; Simpson Thomas J; Ali Mumtaz; Arfan Mohammad; Uddin Ghias

来源：Phytochemistry Letters, 2014, 7: 6-10.

DOI：10.1016/j.phytol.2013.09.002

• Ligularia thomsonii
• Phenylpropanoid glucosides
• Antioxidant activity

Phytochemical investigation of the aerial parts of Ligularia thomsonii has led to the isolation of three new phenylpropanoid glucosides ligularoside I (1), ligularoside II (2) and ligularoside III (3) along with nine known compounds; cinnamic acid (4), 3-phenylpropanoic acid (5), 3,4,5-trihydroxybenzoic acid (6), 4-hydroxybenzoic acid (7), p-coumaric acid (8), caffeic acid (9), 3,4-dihydroxybenzoic acid (10), kaempferol 3-O-beta-D-glucopyranoside (11) and 3,5-di-O-caffeoylquinic acid (12), hitherto unreported from L. thomsonii. Their chemical structures were elucidated by spectroscopic analysis and chemical transformation. All these compounds were tested for antioxidant activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. Among them, compounds 9, 10 and 12 showed significant antioxidant activity against DPPH radicals with IC50 of 19.6, 23.3 and 8.9 mu m, respectively.

• 出版日期2014-2