Angustilobine and andranginine type indole alkaloids and an uleine-secovallesamine bisindole alkaloid from Alstonia angustiloba

作者：Ku Wai Foong; Tan Shin Jowl; Low Yun Yee; Komiyama Kanki; Kam Toh Seok^*

来源：Phytochemistry, 2011, 72(17): 2212-2218.

DOI：10.1016/j.phytochem.2011.08.001

• Apocynaceae
• Alstonia angustiloba
• Alkaloids
• Bisindole
• NMR
• Cytotoxicity

A total of 20 alkaloids were isolated from the leaf and stem-bark extracts of Alstonia angustiloba, of which two are hitherto unknown. One is an alkaloid of the angustilobine type (angustilobine C), while the other is a bisindole alkaloid angustiphylline, derived from the union of uleine and secovallesamine moieties. The structures of these alkaloids were established using NMR and MS analysis. Angustilobine C showed moderate cytotoxicity towards KB cells.

• 出版日期2011-12