Dietary antioxidant capacity and concentration of adiponectin in apparently healthy adults: the ATTICA study

作者：Detopoulou P; Panagiotakos D B^*; Chrysohoou C; Fragopoulou E; Nomikos T; Antonopoulou S; Pitsavos C; Stefanadis C

来源：European Journal of Clinical Nutrition, 2010, 64(2): 161-168.

DOI：10.1038/ejcn.2009.130

• adiponectin
• diet
• antioxidant capacity
• inflammation

Background/Objectives: This study aimed at evaluating the relationship of adiponectin concentration with total dietary antioxidant capacity in free-living, apparently healthy adults from the ATTICA study. Subjects/Methods: A random subsample from the ATTICA study, consisting of 310 men (40 +/- 11 years) and 222 women (38 +/- 12 years), was selected. Adiponectin, along with other inflammatory markers, was measured in fasting participants. Dietary habits were evaluated using a food frequency questionnaire and the dietary antioxidant capacity was based on published values of Italian foods measured by three different assays: ferric-reducing antioxidant power (FRAP), total radical-trapping antioxidant parameters (TRAP) and trolox-equivalent antioxidant capacity (TEAC). Results: Positive associations were observed between dietary antioxidant capacity and adiponectin concentration, as assessed with FRAP (b +/- s.e. 0.012 +/- 0.005, P = 0.018 per 1 mmol Fe (II)/day), TRAP (b +/- s.e. 0.030 +/- 0.013, P = 0.017 per 1 mmol trolox equivalent/day) and TEAC (b +/- s.e. 0.025 +/- 0.012, P = 0.042, per 1 mmol trolox equivalent/day) in multiadjusted analysis. Moreover, a negative relation of dietary antioxidant indices with inflammatory markers was revealed. Conclusions: Diets with high antioxidant capacity are related to increased adiponectin levels. An adiponectin-mediated route through which antioxidant-rich foods exert beneficial effects against inflammation and cardiovascular diseases can be thus hypothesized. European Journal of Clinical Nutrition (2010) 64, 161-168; doi: 10.1038/ejcn.2009.130; published online 11 November 2009

• 出版日期2010-2