Dietary management of presumptive protein-losing enteropathy in Yorkshire terriers

作者：Rudinsky A J^*; Howard J P; Bishop M A; Sherding R G; Parker V J; Gilor C

来源：Journal of Small Animal Practice, 2017, 58(2): 103-108.

DOI：10.1111/jsap.12625

OBJECTIVES: To describe the clinical outcome of dietary management of Yorkshire terriers with protein-losing enteropathy without immunosuppressive/anti-inflammatory medications.
METHODS: Records were searched for Yorkshire terriers with hypoalbuminaemia and a clinical diagnosis of protein-losing enteropathy that were managed with diet and without immunosuppressive/antiinflammatory medications. Serum albumin changes were compared using a one-way repeated measures ANOVA. Canine chronic enteropathy clinical activity index scores were compared using a Wilcoxon signed-rank test.
RESULTS: Eleven cases were identified. Clinical signs were variable including: diarrhoea, respiratory signs, vomiting, lethargy and weight loss. Diets fed included home cooked (n = 5); Royal Canin Gastrointestinal Low Fat (n = 4); Hill's Prescription Diet i/d Low Fat (n = 1); or Purina HA Hypoallergenic (n = 1). Clinical signs resolved completely in eight dogs, partially resolved in two dogs and failed to respond in one dog. In dogs that responded, albumin significantly improved from baseline (mean 14.9 g/L, sd +/-3.7), at 2 to 4 weeks (mean 24.2 g/L, sd +/-5.5, P = 0.01), and at 3 to 4 months (mean 27.0 g/dL, sd +/-5.9, P = 0.01).
CLINICAL SIGNIFICANCE: These results indicate that dietary management of protein-losing enteropathy is a potential management strategy in Yorkshire terriers. Randomised clinical trials in Yorkshire terriers with protein-losing enteropathy are necessary to compare success rate, survival and quality of life with dietary management versus combined dietary and immunosuppressive/anti-inflammatory therapy.

• 出版日期2017-2