Tupisteroide A-C, three new polyhydroxylated steroidal constituents from the roots of Tupistra chinensis

作者：Liu, Cheng-Xiong; Guo, Zhi-yong; Xue, Yan-Hong; Zhang, Hong-Yan; Zhang, Hong-Qi; Zou, Kun^*; Huang, Nian-Yu

来源：Magnetic Resonance in Chemistry, 2012, 50(4): 320-324.

DOI：10.1002/mrc.2861

• NMR
• 1H NMR
• 13C NMR
• 2-D NMR
• steroidal saponin
• Tupistra chinensis

Three new steroidal compounds with polyhydroxy groups, tupisteroide AC (13), were obtained from the roots of Tupistra chinensis, together with one known compound (4) that was isolated from this plant for the first time. The structures of tupisteroide AC were determined on the basis of one- and two-dimensional NMR spectroscopy, including 1H1H Correlation Spectroscopy, Heteronuclear Multiple Bond Correlation, and Heteronuclear Single Quantum Coherence experiments. The isolated compounds were evaluated for their cytotoxic activities against A549, HepG2, and CaSki cancer cell lines in vitro. Among them, compounds 1, 2, and 4 did not show significant inhibitory activity, but compound 3 showed cytotoxicity against A549 cancer cell lines with IC50 values of 25.0 mu M.

• 出版日期2012-4
• 单位三峡大学