Antigenotoxic and free radical scavenging activities of extracts from Moricandia arvensis

作者：Skandrani I; Ben Sghaier M; Neffati A; Boubaker J; Bouhlel I; Kilani S; Mahmoud A; Ghedira K; Chekir Ghedira L^*

来源：Drug and Chemical Toxicology, 2007, 30(4): 361-382.

DOI：10.1080/01480540701522494

• antigenotoxic effect
• Free radical scavenging activity
• Moricandia arvensis
• SOS response

This study evaluates genotoxic and antigenotoxic effects of extracts from leaves of Moricandia arvensis, which are used in traditional cooking and medicines. Extracts showed no genotoxicity when tested with the SOS Chromotest using E. coli PQ37 and PQ35 strains, except for the total oligomers flavonoids enriched extract. Petroleum ether and methanol extracts are the most active in reducing nitrofurantoin genotoxicity, whereas methanol and total oligomers flavonoids enriched extracts showed the most important inhibitory effect of H2O2 genotoxicity. In addition, these two extracts showed important free radical scavenging activity toward the DPPH radical, whereas the chloroform extract exhibited the highest value of TEAC against ABTS(+) radical.

• 出版日期2007