Long noncoding RNAs: Novel molecules in cardiovascular biology, disease and regeneration

作者：Hou, Jingying; Zhou, Changqing; Long, Huibao; Zheng, Shaoxin; Guo, Tianzhu; Wu, Quanhua; Wu, Hao; Zhong, Tingting; Wang, Tong^*

来源：Experimental and Molecular Pathology, 2016, 100(3): 493-501.

DOI：10.1016/j.yexmp.2016.05.006

• Long noncoding RNAs
• Cardiovascular biology
• Cardiovascular disease
• Stem cells
• Cardiac regenerative medicine

Remarkable breakthroughs made in genomic technologies have facilitated the discovery of thousands of novel transcripts that do not template protein synthesis. Numerous RNAs termed as long noncoding RNAs (lncRNAs) generated from this pervasive transcription function vividly in gene regulatory networks and a variety of biological and cellular processes. Here, we make a brief description of the known and putative functions of lncRNAs in cardiovascular biology and disease. The association between lncRNAs and stem cells mediated cardiomyocytes differentiation and neovascularization is discussed then. It will provide a new clue for further studies on these novel molecules in cardiovascular disease and bring bright prospects for their future applications in cardiac regenerative medicine.

• 出版日期2016-6
• 单位中山大学