A Disrupted-in-Schizophrenia 1 Gene Variant is Associated with Clinical Symptomatology in Patients with First-Episode Psychosis

作者：Vazquez Bourgon Javier^*; Mata Ignacio; Roiz Santianez Roberto; Ayesa Arriola Rosa; Pinilla Paula Suarez; Tordesillas Gutierrez Diana; Luis Vazquez Barquero Jose; Crespo Facorro Benedicto

来源：Psychiatry Investigation, 2014, 11(2): 186-191.

DOI：10.4306/pi.2014.11.2.186

• DISCI ser704cys
• Genetics
• Hallucinations
• Schizophrenia
• Severity of illness

Objective DISC1 gene is one of the Main candidate genes for schizophrenia since it has been associated to the illness in several populations. Moreover Variations in several DISC1 polymorphisms, and hi particular Ser704Cys SNP, have been associated in schizophrenic patients to structural and functional Modifications in two brain areas (pre-frontal cortex and hippocampus) that play a central role in the genesis of psychotic symptoms. This study tested the association between Ser704Cys DISCI polymorphism and the clinical onset of psychosis.
Methods Two hundred and thirteen Caucasian drug-naive pater-As experiencing a first episode of non-affective psychosis were genotyped for rs821616 (Ser704Cys) SNP Of the DISCI gene The clinical severity of the illness was assessed using SAPS and SANS scales. Other clinical and socio-demographic Variables were recorded to rule out possible confounding effects.
Results Patients homozygous for the Set allele of the Ser704Cys DISC1 SNP had significantly (p<0.05) higher rates at the positive symptoms dimension (SAP-SANS scales) and hallucinations item, compared to Cys carriers.
Conclusion DISCI gene variations may modulate the clinical severity-of the psychosis at the onset of the disorder.

• 出版日期2014-4