Multifunctional microbubbles and nanobubbles for photoacoustic and ultrasound imaging

作者：Kim Chulhong; Qin Ruogu; Xu Jeff S; Wang Lihong V^*; Xu Ronald

来源：Journal of Biomedical Optics, 2010, 15(1): 010510.

DOI：10.1117/1.3302808

• microbubbles
• nanobubbles
• photoacoustic imaging
• ultrasound imaging
• tumor margin intraoperative assessment

We develop a novel dual-modal contrast agent-encapsulated-ink poly(lactic-co-glycolic acid) (PLGA) microbubbles and nanobubbles-for photoacoustic and ultrasound imaging. Soft gelatin phantoms with embedded tumor simulators of encapsulated-ink PLGA microbubbles and nanobubbles in various concentrations are clearly shown in both photoacoustic and ultrasound images. In addition, using photoacoustic imaging, we successfully image the samples positioned below 1.8-cm-thick chicken breast tissues. Potentially, simultaneous photoacoustic and ultrasound imaging enhanced by encapsulated-dye PLGA microbubbles or nanobubbles can be a valuable tool for intraoperative assessment of tumor boundaries and therapeutic margins.

• 出版日期2010-2