Efficient Method for the Synthesis of Functionalized Basic Maleimides

作者:Salewska Natalia; Milewska Maria J*
来源:Journal of Heterocyclic Chemistry, 2014, 51(4): 999-1003.
DOI:10.1002/jhet.1651

摘要

A three-step procedure involving Diels-Alder condensation of maleic anhydride with furane, formation of N-substituted imide upon reaction with appropriate diamine, and a final retro Diels-Alder regeneration of the maleic carbon-carbon double bond is proposed for an unequivocal synthesis of N-substituted basic maleimides. The novel method is characterized by mild reaction conditions, easy work-up, high yields, and no need for additional catalysis.

  • 出版日期2014-7

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