A novel HLA-B*57 (B*5714) allele in a healthy male Caucasian individual

作者：Altermann W W^*; Grondkowski V; Reichert S; Seliger B; Schlaf G

来源：Tissue Antigens, 2008, 71(3): 253-254.

DOI：10.1111/j.1399-0039.2007.00999.x

• DNA single allele sequencing
• human leucocyte antigen-B*5714
• human leucocyte antigen-B57

A novel human leucocyte antigen (HLA)-B57 (HLA-B*5714) allele has been identified in a male Caucasian individual from Middle Europe using single allele-specific sequencing strategy. This allele is identical to the HLA-B*570101 allele except for two point mutations in exon 3 at codon 138 (ACG --> ACC) with no amino acid change [persisting threonine IT)] and at codon 171 (TAC --> CAC), resulting in an amino acid change from tyrosine (Y) to histidine (H).

• 出版日期2008-3
• 单位河北医科大学