Are synthetic scaffolds suitable for the development of clinical tissue-engineered tubular organs?

作者：Del Gaudio Costantino; Baiguera Silvia; Ajalloueian Fatemeh; Bianco Alessandra; Macchiarini Paolo^*

来源：Journal of Biomedical Materials Research Part A, 2014, 102(7): 2427-2447.

DOI：10.1002/jbm.a.34883

• tissue engineering
• organs and tissues
• synthetic biomaterials
• in vitro and in vivo evaluation

Transplantation of tissues and organs is currently the only available treatment for patients with end-stage diseases. However, its feasibility is limited by the chronic shortage of suitable donors, the need for life-long immunosuppression, and by socioeconomical and religious concerns. Recently, tissue engineering has garnered interest as a means to generate cell-seeded three-dimensional scaffolds that could replace diseased organs without requiring immunosuppression. Using a regenerative approach, scaffolds made by synthetic, nonimmunogenic, and biocompatible materials have been developed and successfully clinically implanted. This strategy, based on a viable and ready-to-use bioengineered scaffold, able to promote novel tissue formation, favoring cell adhesion and proliferation, could become a reliable alternative to allotransplatation in the next future. In this article, tissue-engineered synthetic substitutes for tubular organs (such as trachea, esophagus, bile ducts, and bowel) are reviewed, including a discussion on their morphological and functional properties.

• 出版日期2014-7