A Flow Process Using Microreactors for the Preparation of a Quinolone Derivative as a Potent 5HT(1B) Antagonist

作者：Qian Zizheng; Baxendale Ian R; Ley Steven V^*

来源：Synlett, 2010, (4): 505-508.

DOI：10.1055/s-0029-1219358

• flow chemistry
• solid-supported reagent
• microreactor

This article describes the continuous flow synthesis of 6-methoxy-8-(4-methyl-1,4-diazepan-1-yl)-N-(4-morpholinophenyl)-4-oxo-1,4-dihydroquinoline-2-carboxamide, a potent 5HT(1B) antagonist developed by AstraZeneca.

• 出版日期2010-3