A novel class of potent influenza virus inhibitors: Polysubstituted acylthiourea and its fused heterocycle derivatives

作者：Sun, CW^*; Huang, H; Feng, MQ; Shi, XL; Zhang, XD; Zhou, P

来源：Bioorganic & Medicinal Chemistry Letters, 2006, 16(1): 162-166.

DOI：10.1016/j.bmcl.2005.09.033

• influenza virus
• inhibitor
• acylthioureas
• heterocycle
• antiviral activity

A series of polysubstituted and fused heterocycle derivatives of acylthiourea was prepared and the biological activity against influenza virus was evaluated. Of the analogues that demonstrated IC(50)s < 0.1 mu M, acylthiourea derivatives 16 and 50 were further investigated as candidates with the most potential for future development. The SAR of these compounds are discussed and they represent a novel class of highly potent and selective inhibitors of influenza virus.

• 出版日期2006-1-1
• 单位上海交通大学