Assessment of Angiogenic Markers and Female Sex Hormone Receptors in Pregnancy Tumor of the Gingiva

作者：Andrikopoulou Maria; Chatzistamou Ioulia^*; Gkilas Harry; Vilaras George; Sklavounou Alexandra

来源：Journal of Oral and Maxillofacial Surgery, 2013, 71(8): 1376-1381.

DOI：10.1016/j.joms.2013.03.009

Purpose: Oral pregnancy tumors (OPTs) arise on the inflamed gingiva of women after the first trimester of pregnancy. The expression of angiogenic markers and female hormone receptors was assessed. %26lt;br%26gt;Materials and Methods: Immunohistochemistry was used to analyze the expression of estrogen and progesterone receptors and the expression of angiogenic factors, such as vascular endothelial growth factor (VEGF) and its receptor, fibroblast growth factor (FGF), and hypoxia inducible factors 1 alpha and 3 alpha (HIF1 alpha and HIF3 alpha). Experimental groups included 9 OPTs, 10 oral pyogenic granulomas from nonpregnant women of the same age, and 9 oral pyogenic granulomas from postmenopausal women. %26lt;br%26gt;Results: VEGF expression in stromal histiocytes and endothelial cells of small vessels was positively correlated in the OPT group (P %26lt; .05 by chi(2) test). VEGF receptor also was overexpressed in stromal histiocytes and endothelial cells of OPTs compared with oral pyogenic granulomas from nonpregnant and postmenopausal women (P %26lt; .005 by chi(2) test). No correlation was detected among estrogen and progesterone receptors, FGF and HIF1 alpha and HIF3 alpha (ER and PgR respectively) in the 3 experimental groups. %26lt;br%26gt;Conclusions: VEGF-associated angiogenesis is most likely involved in the pathogenesis of the lesion. These results imply that local inhibition of VEGF activity could be an adjuvant therapeutic approach for OPTs to control hemorrhage, which can be massive at the surgical excision of such lesions during pregnancy.

• 出版日期2013-8