A synthetic and in silico study on the highly regioselective Diels-Alder reaction of the polyenic antifungal antibiotics natamycin and flavofungin

作者：Fejes Zsolt; Mandi Attila; Komaromi Istvan^*; Majoros Laszlo; Batta Gyula; Herczegh Pal

来源：Tetrahedron Letters, 2010, 51(38): 4968-4971.

DOI：10.1016/j.tetlet.2010.07.049

The tetraenic macrolide antibiotic natamycin and the pentaenic macrolide flavofungin gave monoadducts on Diels-Alder reaction with 4-phenyl-1,2,4-triazoline-3,5-dione. The regioselectivity of the reaction as well as the conformation of the products was studied using theoretical calculations.

• 出版日期2010-9-22