A chemical reporter strategy for detecting and identifying O-mycoloylated proteins in Corynebacterium

作者:Kavunja Herbert W; Piligian Brent F; Fiolek Taylor J; Foley Hannah N; Nathan Temitope O; Swarts Benjamin M*
来源:Chemical communications, 2016, 52(95): 13795-13798.
DOI:10.1039/c6cc07143k

摘要

Protein O-mycoloylation is a unique post-translational lipidation that was recently discovered in Corynebacterium. We describe an alkyne-modified trehalose monomycolate chemical reporter that can meta-bolically tag O-mycoloylated proteins in C. glutamicum, enabling their detection and identification through click chemistry.

  • 出版日期2016