Aryl-linked imidazolidin-2-ones as non-peptidic beta-strand mimetics

作者:Sutherell Charlotte L; Thompson Sam; Scott Richard T W; Hamilton Andrew D*
来源:Chemical Communications, 2012, 48(79): 9834-9836.
DOI:10.1039/c2cc34791a

摘要

We describe the design and synthesis of a non-peptidic beta-strand mimetic composed of alternating aryl and imidazolidin-2-one rings that can be adapted to display diverse side-chains. Solid-and solution-phase data together with calculations suggest that the desired conformation for side-chain mimicry is readily accessible and well-populated.

  • 出版日期2012