An expedient pseudo four-component synthesis of dispiroindandione fused indeno-N-methylmorpholine, spectroscopic, X-ray diffraction and DFT studies

作者：Almansour Abdulrahman I; Arumugam Natarajan^*; Kumar Raju Suresh; Padmanaban R; Rajamanikandan V B; Ghabbour Hazem A; Fun Hoong Kun

来源：Journal of Molecular Structure, 2014, 1063: 283-288.

DOI：10.1016/j.molstruc.2014.01.075

• Spiroheterocycle
• Cascade cycloaddition reaction
• X-ray diffraction studies
• DFT-calculation

Synthesis of a novel heterocycle comprising N-methylmorpholine, spiroindandione and indenone units in good yield via one-pot pseudo four-component cascade cycloaddition reaction is described. The structure of the cycloadduct was elucidated by spectroscopic analysis and its complete stereochemistry was assigned by single crystal X-ray diffraction analysis. Further, the mechanistic rationalization for the formation of the hitherto unexpected cycloadduct is provided by performing density functional theory (DFT) calculations.

• 出版日期2014-4-24