Detection of diminished response to cold pressor test in smokers: Assessment using phase-contrast cine magnetic resonance imaging of the coronary sinus

作者：Kato Shingo; Kitagawa Kakuya^*; Yoon Yeonyee E; Nakajima Hiroshi; Nagata Motonori; Takase Shinichi; Nakamori Shiro; Ito Masaaki; Sakuma Hajime

来源：Magnetic Resonance Imaging, 2014, 32(3): 217-223.

DOI：10.1016/j.mri.2013.12.015

• Phase-Contrast Cine Magnetic Resonance
• Imaging
• Cold Pressor Test
• Coronary endothelial function
• Smoker
• 3 T MR imager
• Nitric oxide

Purpose: The purposes of this study were to evaluate the reproducibility for measuring the cold pressor test (CPT)-induced myocardial blood flow (MBF) alteration using phase-contrast (PC) cine MRI, and to determine if this approach could detect altered MBF response to CPT in smokers. %26lt;br%26gt;Materials and methods: After obtaining informed consent, ten healthy male non-smokers (mean age: 28 +/- 5 years) and ten age-matched male smokers (smoking duration %26gt;= 5 years, mean age: 28 +/- 3 years) were examined in this institutional review board approved study. Breath-hold PC cine MR images of the coronary sinus were obtained with a 3 T MR imager with 32 channel coils at rest and during a CPT performed after immersing one foot in ice water. MBF was calculated as coronary sinus flow divided by the left ventricular (LV) mass which was given as a total LV myocardial volume measured on cine MRI multiplied by the specific gravity (1.05 g/mL). %26lt;br%26gt;Results: In non-smokers, MBF was 0.86 +/- 0.25 mL/min/g at rest, with a significant increase to 1.20 +/- 0.36 mL/min/g seen during CPT (percentage change of MBF (Delta MBF (%)); 39.2 +/- 14.4%, p %26lt; 0.001). Inter-study reproducibility for Delta MBF (%) measurements by different MR technologist was good, as indicated by the intraclass correlation coefficient of 0.93 and reproducibility coefficient of 10.5%. There was no significant difference between smokers and non-smokers for resting MBF (0.85 +/- 0.32 mL/min/g, p = 0.91). However, Delta MBF (%) in smokers was significantly reduced (-4.0 +/- 32.2% vs. 39.2 +/- 14.4%, p = 0.011). %26lt;br%26gt;Conclusion: PC cine MRI can be used to reproducibly quantify MBF response to CPT and to detect impaired flow response in smokers. This MR approach may be useful for monitoring the sequential change of coronary blood flow in various potentially pathologic conditions and for investigating its relationship with%26apos; cardiovascular risk.

• 出版日期2014-4