Uterine volume and endometrial thickness in healthy girls evaluated by ultrasound (3-dimensional) and magnetic resonance imaging

作者：Hagen Casper P^*; Mouritsen Annette; Mieritz Mikkel G; Tinggaard Jeanette; Wohlfahrt Veje Christine; Fallentin Eva; Brocks Vibeke; Sundberg Karin; Jensen Lisa Neerup; Juul Anders; Main Katharina M

来源：Fertility and Sterility, 2015, 104(2): 452-+.

DOI：10.1016/j.fertnstert.2015.04.042

• Uterus
• endometrium
• puberty
• TAUS
• MRI

Objective: To report normative data on uterine volume and endometrial thickness in girls, according to pubertal stages; to evaluate factors that affect uterine volume; and to compare transabdominal ultrasound (TAUS) and magnetic resonance imaging (MRI).
Design: Cross-sectional study of a nested cohort of girls participating in The Copenhagen Mother-Child Cohort.
Setting: General community.
Patient(s): One hundred twenty-one healthy girls, aged 9.8-14.7 years.
Intervention(s): None.
Main Outcome Measure(s): Clinical examination, including pubertal breast stage (Tanner classification: B1-B5). Uterine volume: ellipsoid TAUS (n = 112) and 3-dimensional TAUS (n = 111); ellipsoid MRI (n = 61). Endometrial thickness: TAUS (n = 110) and MRI (n = 60).
Result(s): Uterine volume and endometrial thickness were positively correlated with pubertal stages; e.g., ellipsoid TAUS: r = 0.753, and endometrium TAUS: 0.648. In multiple regression analyses, uterine volume was associated with the number of large follicles (TAUS >5 mm) (Beta 0.270); estradiol (E-2) (Beta 0.504); and height (Beta 0.341). Volumes from ellipsoid vs. 3-dimensional TAUS were strongly correlated (r = 0.931), as were TAUS and MRI: ellipsoid volume (r = 0.891) and endometrial thickness (r = 0.540). Uterine volume was larger in TAUS compared with MRI; mean difference across the measured range: 7.7 (5.2-10.2) cm(3). Agreement was best for small uteri.
Conclusion(s): Uterine volume and endometrial thickness increased as puberty progressed. Circulating E-2 from large follicles was the main contributor to uterine and endometrial growth. The TAUS and MRI assessments of uterus and endometrium were strongly correlated.

• 出版日期2015-8