Multi-component one-pot synthesis of novel coumarinyldihydropyridines under solvent free conditions

作者：Bohra Kapil; Sharma Deepti; Kumar Banty; Olsen Carl E; Parmar Virinder S; Prasad Ashok K^*

来源：Journal of the Indian Chemical Society, 2013, 90(10): 1885-1891.

• Hantzsch 1,4-dihydropyridines
• 4-formylcoumarins
• barium nitrate
• beta-ketoesters
• ammonium acetate
• solventfree
• conditions

A library of fourteen 4-coumarinyl-1,4-dihydropyridines (coumarinyl-1,4-DHP) has been synthesized under modified Hantzsch 1,4-dihydropyridine synthesis condition by the condensation of 4-formylcoumarin, alkyl acetoacetate and ammonium acetate in the presence of Ba(NO3)(2) as a catalyst in 58 to 82% yields. Standardization of reaction conditions revealed that 10 mol% of Ba(NO3)(2) is enough for optimum yields. The developed methodology does not require the use of organic solvents and hence makes the process eco-friendly. The structure of all the coumariny1-1,4-DHPs were unambiguously eastablished on the basis of IR, H-1, C-13 NMR spectroscopy and HRMS data analysis.

• 出版日期2013-10