The fetal fraction of cell-free DNA in maternal plasma is not affected by a priori risk of fetal trisomy

作者：Brar Herb; Wang Eric; Struble Craig; Musci Thomas J^*; Norton Mary E

来源：Journal of Maternal-Fetal and Neonatal Medicine, 2013, 26(2): 143-145.

DOI：10.3109/14767058.2012.722731

• Non-invasive
• prenatal diagnosis
• cell-free DNA
• trisomy risk

Objective: To determine the relationship between a priori risk for fetal trisomy and the fraction of fetal cell-free DNA (cfDNA) in maternal blood. Methods: A comparative analysis on fetal cfDNA amounts was performed in subjects stratified into a priori risk groups based on maternal age, prenatal screening results, or nuchal translucency measurement. Results: Across the highest and lowest deciles within each group, there were no significant differences in the fetal cfDNA fraction. Conclusions: These data support the concept that non-invasive prenatal test performance as determined by fetal cfDNA fraction is not predicted to be different based on patient risk classification.

• 出版日期2013-1